Safety upgrades for the D'Aguilar Highway in Queensland will be funded by $16 million of federal government money.
New traffic signs are part of the changes, with work also including the construction of new turning lanes and rail guards, improved drainage and better line markings on dangerous sections of the highway.
Assistant minister for infrastructure and regional development Jamie Briggs and Wyatt Roy, federal member for Longman, toured key sites earmarked for development on Tuesday (October 29).
"We are now ready to begin the job of delivering a safer D'Aguilar Highway," Mr Roy said.
"We will also be talking to the Queensland government about a funding contribution to the project."
He added that there had been too many unnecessary fatalities and injuries on the road, which the safety upgrades should prevent in the future.
Sites set to receive work include the Gamgee Road and Canando Street intersections, while the installation of additional guardrails will be carried out between King Street and Bracalba Quarry.
Enhanced drainage systems will also be deployed at Mylett Road to Wararba Creek.
The funding is being provided under the government's Infrastructure Investment Programme and projects are expected to get underway in 2014-15.